![]() ![]() Among Caucasians over 90% of patients with narcolepsy-cataplexy are HLA DQB1*0602 positive. Typically narcolepsy-cataplexy is characterized by the lack of hypothalamic hypocretin (orexin) production, and strong association with HLA DR15 (DR2) and DQB1*0602,. An onset before age of 10 years has been rare. ![]() Most often narcolepsy starts between 12–25 years of age with the main peak of onset at 14–16 years. The most common symptoms of narcolepsy are unintended sleep episodes, excessive daytime sleepiness (EDS) and cataplexy. the incidence is estimated to be 0.74 per 100 000 person-years for narcolepsy with cataplexy and 1.37 per 100 000 person-years for narcolepsy with or without cataplexy. The reported prevalence of narcolepsy-cataplexy among adults in Finland is 26 cases/100 000 inhabitants (95% confidence interval CI of 0 to 60). The authors had access to all the data, take responsibility for the integrity of the data and the accuracy of the analysis, and had final responsibility for the reporting of the data.Ĭompeting interests: The authors have declared that no competing interests exist. The study group had freedom for the study design, data collection, data analysis, data interpretation, and writing of the report. The collection of data from the registries and from different hospitals was funded by THL. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: The authors have no external support or funding to report. Received: NovemAccepted: FebruPublished: March 28, 2012Ĭopyright: © 2012 Partinen et al. Cowling, University of Hong Kong, Hong Kong (2012) Increased Incidence and Clinical Picture of Childhood Narcolepsy following the 2009 H1N1 Pandemic Vaccination Campaign in Finland. Otherwise the clinical picture was similar to that described in childhood narcolepsy.Ĭitation: Partinen M, Saarenpää-Heikkilä O, Ilveskoski I, Hublin C, Linna M, Olsén P, et al. Forty-seven (94%) had cataplexy, which started at the same time or soon after the onset of EDS. All 50 had EDS with abnormal multiple sleep latency test (sleep latency <8 min and ≥2 sleep onset REM periods). 50/54 children had received Pandemrix vaccination 0 to 242 days (median 42) before onset. Thirty-four of the 54 children were HLA-typed, and they were all positive for narcolepsy risk allele DQB1*0602/DRB1*15. Among adults ≥20 years of age the incidence rate in 2010 was 0.87/100 000, which equals that in 2002–2009. In 2010, 54 children under age 17 were diagnosed with narcolepsy (5.3/100 000 17-fold increase). The average annual incidence among subjects under 17 years of age was 0.31 (0.12–0.51) per 100 000 inhabitants. Altogether 335 cases (all ages) of narcolepsy were diagnosed in Finland during 2002–2009 giving an annual incidence of 0.79 per 100 000 inhabitants (95% confidence interval 0.62–0.96). ![]()
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